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Regenerative medicine iprf

The Next Generation of PRP

Injectable Platelet Rich Fibrin (i-PRF) is the next generation of PRP. i-PRF offers an innovative concept to overcome previous limitations within regenerative medicine.  i-PRF offers excellent cell viability and bio compatibility with superior tissue regeneration. This advanced form of platelet rich plasma does not use anticoagulants or other chemical based additives, therefore offers a completely natural treatment to improve volume loss, photo damage, fine lines and wrinkles, scars, pigmentation, poor texture and hair loss.

The low speed centrifugation concept (LSCC) guarantees a higher concentration of platelets, growth factors and leukocytes which become trapped within the fibrin mesh resulting in a cell rich network. These essential cells are then released slowly to lead to a natural regeneration process. 

Studies prove the i-PRF Smart Cell System offers a significantly higher concentration of platelets when compared to PRP following centrifugation, which highlights the superiority of Injectable Platelet Rich Fibrin and why this system is a true game changer.

CELL CONCENTRATION

GROWTH FACTORS

7 Fundamental growth factors are released by platelets:

EGF, PDGF, VGF, IGF, KGF, TGF-B, FGF 

PLATELETS

 Platelets only release growth factors once activated.

Anticoagulant inhibits the activation of platelets

LEUKOCYTES

Leukocytes have a strong influence on the release of growth factors

Leukocyte rich plasma releases larger amounts of molecules

Superior for wound healing – scars and skin needling

CELL RICH

i-PRF Smart Cell system contains activated platelets, leukocytes (WBC) & mesenchymal stem cells

MEDICAL DEVICE

The i-PRF Smart Cell system uses biocompatible medical device (class IIb) tubes specifically designed for autologous therapy

FIBRIN MESH

Fibrinogen is the key. The fibrin mesh traps the platelets, growth factors and bioactive molecules

100% NATURAL

 i-PRF Smart Cell system is 100% natural, completely free of chemicals, additives or clotting factors

iPRF training

Hair Therapy

iPRF Hair

i-PRF is an all natural autologous treatment that stimulates hair growth where hair follicles are present but inactive.

Research shows that the higher concentration of platelets, leukocytes and presence of fibrin is superior to PRP as it can enhance the growth of hair follicles by stimulating the stem cells and other cells in the microenvironment of the hair follicle.

Fibrin functions as a matrix that traps the platelets and controls their release of growth factors “very slowly and continuously over 7-10 days. Growth factors release rate into the target tissue is important for tissue receptors to respond over a prolonged period of time following treatment. 

Platelets release 7 fundamental growth factors: PDGF, FGF, VEGF, EGF, KGF, IGF, TGF-β

For patients with significant hair loss, then a combined approach is often recommended, i-PRF works well for both men and women, especially those in the early stages of hair loss. 

Skin Rejuvenation

Injectable platelet‐rich fibrin stimulates greater dermal skin fibroblast cell migration, proliferation, and collagen synthesis when compared to platelet‐rich plasma.

Skin fibroblasts migrated over 350% more with i-PRF when compared to PRP (200% increase). i-PRF also significantly induces greater cell proliferation and significantly greater ability to induce collagen matrix synthesis when compared to PRP.

i-PRF yields more than double the number of platelets which play a critical role in tissue repair and regeneration, they regulate fundamental mechanisms involved in the healing process including cellular migration, proliferation, and angiogenesis.

i-PRF is proven to be the gold standard in natural skin rejuvenation. One of the main advantages of using i-PRF as a regenerative modality in various fields of regenerative medicine is its low cost in comparison with other regenerative modalities or recombinant growth factors/hormones.

This therapy is entirely autologous without any chemical additive and offers superior tissue bio-compatibility and tissue regeneration due to the activated platelets and fibrin matrix.

Furthermore, wound healing is drastically improved with i-PRF when compared to PRP as PRP typically contains low concentrations of leukocytes. Leukocytes are the main protagonists in wound healing and the regeneration process. Their presence in autologous therapy increases the regeneration capacity.

iPRF Smart Cell

IN THE PRESS

New Beauty PRP.JPG

August 17, 2017

Next Generation

Platelet-rich plasma (PRP) has experienced substantial growth in the aesthetic community over the last few years—it's currently being used to rejuvenate the skin in "vampire facials"...

New Beauty IPRF.JPG

January 10, 2018

Breakthrough

The New ‘Natural’ Filler That Uses Your Own Blood to Plump Up Your Skin. Starting in our 30s, we lose volume in our face—under our eyes, in our cheeks and around our mouths. Later on, in our 40s and...

January 14, 2018

Ultimate Blood Concentrate

FACIAL AGEING IS A COMPLEX process not yet fully understood. Synthetic facial fillers and collagen stimulators, while invaluable tools, do not represent the ideal...

i-PRF Equipment

iPRF Smart Cell Centrifuge is the smallest centrifuge on the market capable of hosting up to 6 x 13ml tubes.

 

It has been pre-configured with our customized i-PRF Smart Cell settings, and retains the ability to be set manually should the user feel the need to use a different centrifugation speed and time.

Price: £750.00+vat

DOWNLOAD i-PRF Smart Cell Centrifuge Brochure

Smart Cell System Centrifuge.png

We offer 2 different kits.

Kit Option 1: contains 2 x 12ml tubes and will yield 4-8 ml of conditioned plasma. Kit price £45.00

Kit Option 2:  contains 4 x 12ml tubes and will yield 8-16 ml of conditioned plasma. Kit price £70.00

Note: conditioned plasma is client dependent. 

Treatment Kit Contents:

  • 2 x Blood collection 21G butterfly

  • 2 x Luer-lock 2.5ml syringe​

  • 2 x Meso-relle needle 30G x 4mm​

  • 2 x 30G 1 ½” sharp needle​

  • 2 x 30G x 13mm needle​

  • 12ml i-PRF Smart Cell vacutainers (2 or 4)

i-PRF Smart Cell vacutainers (12ml) for Injectable Platelet Rich Fibrin (iPRF) in aesthetics.

Unlike other tubes, the Smart Cell vacutainers come in individual sterile blister packs.

Class IIb medical device.

The tubes comply with all regulatory requirements by the EU Directive 93/42/EEC (CE 0123).

Quantity: 24

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Medical Device EU Directive

Compliance

 

i-PRF Smart Cell tubes are CE 0123, Class IIb Medical Device according to European Commission’s MEDDEV 93/42/EEC, Classification Document Annex IX with the Rule 3 that requires clinical evaluation and biocompatibility tests that lead to the permission of clinical applications.

Published Literature

» iPRF YIELDS HIGHER PLATELET COUNT THAN PRP
Anita Woolley, FIBMS. | Senior Biomedical Scientist |

Sheffield Teaching Hospitals NHS Foundation Trust | STH · Sheffield Haemophilia and Thrombosis Centre |2020

» FLUID PRF (iPRF) STIMULATES GREATER DERMAL SKIN FIBROBLAST THAN PRP

Richard J Miron, Nova Southeastern University. Xuzhu Wang, The University of Hong Kong

Article  in  Journal of Cosmetic Dermatology · April 2019

 
» PRF MAY EXTEND LONGEVITY OF FAT GRAFTS

Shaoheng Xiong, M.D., Lihong Qiu, M.D., Yinjun Su, M.D., Ph.D., Hui Zheng, M.D., Chenggang Yi, M.D., Ph.D.

» ROLE OF PLATELET-RICH FIBRIN IN WOUND HEALING

Balaram Naik, P Karunakar, M Jayadev, and V Rahul Marshal

» GROWTH FACTOR MEASUREMENT AND HISTOLOGICAL ANALYSIS IN PLATELET-RICH FIBRIN

Soh Nishimoto,corresponding author Kazutoshi Fujita, Yohei Sotsuka, Masato Kinoshita, Toshihiro Fujiwara, Kenichiro Kawai, and Masao Kakibuchi

» PLATELET-RICH FIBRIN (PRF) FOR HAIR LOSS

Kian Karimi, M.D., Helena Rockwell, B.Sc.

» THE EFFECT OF PLATELET-RICH FIBRIN ON NASAL SKIN THICKNESS IN RHINOPLASTY

Sercan Gode, M.D., Arin Ozturk, M.D., Erkan Kısmalı, M.D., Veysel Berber, M.D., Goksel Turhal, M.D. | Facial Plast Surg | 2019

» EFFECT OF INJECTABLE PLATELET-RICH FIBRIN ON DICED CARTILAGE’S VIABILITY IN RHINOPLASTY

Sercan Gode, M.D., Arin Ozturk, M.D., Veysel Berber, M.D., Erkan Kısmalı, M.D. | Facial Plast Surg | 2019